Blood Types

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Questions and Answers

  1. In the ABO blood type system, A and B are the codominant alleles that have dominance over the recessive O allele. If a person that has the AB blood type has a child with someone with a type O blood, what are the most likely blood types the child would form? The blood type that the child would most likely form is either A or B. In addition to the ABO blood types, the red blood cells can also express another surface protein that is called the Rhesus (Rh) factor. This is a trait that typically has a dominant/recessive inheritance pattern where the alleles that produce the Rhesus protein phenotype (Rh+) is dominant over the allele that results in the lack of Rhesus protein phenotype (Rh-). What are the possible ABO and Rh genotypes of an individual with type B+ blood? (hint: there are four; one is provided for you to get started)

BB++, BB+-, BB--, BB+-

  1. The diagram below shows the ABO and Rh (+ or -) phenotypes in my family.

/Users/kfisher/Desktop/ABO.jpg

Based on these blood type phenotypes, what are the only possible ABO and Rh genotypes of:

  1. my mom? ABO: OO Rh:XX'
  2. my dad? ABO: AA Rh: XY
  3. me? ABO: AO Rh: XX'
  4. my brother? ABO: OO Rh: XY

Hemophilia is a condition in which blood clotting proteins do not function properly, resulting in excessive bleeding upon injury. It is caused by mutations to the F8 gene located on the X chromosome: the F8 gene codes for a protein coagulation factor necessary for proper blood clot formation.

The pedigree below depicts a family in which the grandfather was a hemophiliac (‘H’). Triangles denote males (XY) and circles represent females (XX).

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